J Ethnopharmacol. Epub Dec 4. Endopleura uchi Huber Cuatrec. Electronic address: beatriz. Electronic address: charmed gmail. Electronic address: Krynyroberta07 gmail.
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This article has been cited by other articles in PMC. Abstract Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.
Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC50 values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration.
The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. Keywords: Endopleura uchi, minimum inhibitory concentration, IC50, tannins 1. Introduction Nowadays, in spite of great developments in organic synthesis and new biotechnological processes, a notable increase in phytotherapeutic practice can be observed.
In Brazil, approximately 80, species of plants are described, offering a wide range of raw material for the discovery of new drugs [ 1 ]. The WHO recommends research into the use of the local flora for therapeutic purposes, with the intention of reducing the number of people excluded from effective therapy in the government health systems, which could constitute an economically viable alternative treatment of several diseases, especially in developing countries [ 3 , 4 ].
The abusive and indiscriminate use of antimicrobial compounds over many years is the main factor responsible for the appearance of the phenomenon of bacterial resistance to such compounds [ 5 ]. Several alternatives have been suggested to solve this problem such as the search for new antimicrobials in plant species [ 6 , 7 ]. Some plants synthesize substances to defend themselves when attacked by bacteria, fungi, parasites, viruses or other agents. These compounds are products of their secondary metabolism and of particular interest are those with antimicrobial properties such as: terpenoids monoterpenes, sesquiterpenes, diterpenes and saponins , phenolics simple phenols, tannins, dibenzofurans and flavonoids , nitrogenated compounds alkaloids, cyclic peptides and glycosides , coumarin and camphor [ 8 — 11 ].
Endopleura uchi Huber Cuatrec. Humiriaceae is a native tree of the Brazilian Amazon rainforest and is found scattered over the whole Amazonian Basin. The family Humiriaceae was described by Antoine Laurent de Jussieu and includes 50 species classified in eight genera, spread in tropical areas of America, and one specie in tropical West Africa. The erect trees have pale gray bark and reach between 25 and 30 meters in height, with a stem diameter over one meter.
The bark is widely commercialized at fairs, markets and even drugstores, being prescribed in the form of tea, for arthritis, cholesterol, diabetes, diarrhea treatments and as an anti-inflammatory [ 14 ].
The phytochemical screening of the bark revealed the predominance of tannins, coumarins and saponins as the main classes of secondary metabolites [ 15 ]. In previous work, Luna et al. In this study we determined total tannin contents and investigated the antimicrobial and cytotoxic activities of various extracts of powdered bark of E. Results and Discussion Considering that the aim of the present study was to evaluate the antibacterial effect of powdered bark extracts of E.
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